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TUNE-401 larger Phase 2 starts

After its May 2026 Phase 1b/2a HBV update, Tune said it was advancing a larger Phase 2 study. TUNE-401 uses liver-directed epigenetic silencing of HBV transcriptional reservoirs.

Tune TherapeuticsPrivate biotechTrial initiationDate to watch

What matters

Track what the company has actually announced, the study or asset involved, and the evidence needed to confirm the milestone.

  • A Phase 1b/2a study already exists. Distinguish the larger follow-on protocol and verify whether first dosing has occurred.
  • Research candidate, not a live market, clinical probability, company equity or access to private shares.

Primary evidence

Company target: as early as late 2026; exact day unconfirmed

Company context

Company-authored LinkedIn About explicitly states Type: Privately Held and links tunetx.com. Opened and checked October 31, 2026. This is an undated company self-report, not independent registry proof; it does not establish program outcome status.

Potential outcome market

Will the first participant be dosed in the new larger Phase 2 TUNE-401 study by the market deadline?

This event is research, not a listed market. A market needs a precise question, resolution rules and liquidity before trading opens.